What is TK and PK?

What is TK and PK?

PK is the abbreviation for pharmacokinetics. TK is the abbreviation for toxicokinetics. Pharmacokinetics generally deals with doses that are in a therapeutic range. Thus common dose ranges will include the no pharmacologic effect level on the low end, and the maximum pharmacologic effect level on the high end.

What are the steps of toxicokinetics?

Four processes are involved in toxicokinetics:

  • Absorption — the substance enters the body.
  • Distribution — the substance moves from the site of entry to other areas of the body.
  • Biotransformation — the body changes (transforms) the substance into new chemicals (metabolites).

What is tk4?

San Diego’s TK 4 blends dollars from California’s TK program with funds from the California State Preschool Program (CSPP) to create one program for all 4-year-olds. …

What is prek4?

In PreK 4 the emphasis is on number concepts, literacy skills and small muscle activity. The students will work on early literacy, pre math skills, science and journal writing and much more. Pre- K 4 is based on the International Baccalaureate: Primary Years Programme that begins with the Programme of Inquiry.

What is the difference between toxicology and toxicokinetics?

The science of toxicology has evolved to include environmental and occupational chemicals as well as drugs. Toxicokinetics is thus the appropriate term for the study of the kinetics of all substances at toxic dose/exposure levels.

What is toxicokinetics quizlet?

Toxicokinetics is the study of drug or compound movement around the body (absorption, distribution, metabolism and elimination, ADME- absorption, distribution, metablism, excretion) toxicokinetics is concerned with what the body does to the toxicant.

Which is the best definition of toxicokinetics?

Toxicokinetics is defined as the generation of pharmacokinetic data, either as an integral component in the conduct of preclinical toxicity studies or in specially designed supportive studies, in order to assess systemic exposure. From: A Comprehensive Guide to Toxicology in Nonclinical Drug Development (Second Edition), 2017

How is toxicokinetics ( TK ) and PK related?

TK describes the use of bioanalytical sampling to characterize the disposition of a target compound during time-course toxicity studies in animals. TK is closely related to PK, which is defined as the process of drug absorption, distribution, metabolism, and excretion (ADME) in a living organism.

Why is systemic exposure important in toxicokinetics studies?

Data on systemic exposure becomes particularly important in cases of negative results of in vivo genotoxicity studies [20]. The main purpose of toxicokinetics is to describe the systemic exposure achieved in animals and its relationship to dose level and the time course of the toxicity study.

How is the half-life of toxicokinetics determined?

Half-life (t½) may not be accurately determined in TK studies (although it is frequently estimated) due to relatively sparse sampling of blood or plasma for concentration-time analysis. How Does ADME Influence Toxicokinetics?