What is Zycortal used for?

What is Zycortal and what is it used for? Zycortal is a veterinary medicine used to treat dogs with Addison’s disease. Addison’s disease is a condition, known as hypoadrenocorticism, where the adrenal glands (located above the kidneys) do not produce enough of two steroid hormones, called cortisol and aldosterone.

When do you give Zycortal?

To transfer a dog from fludrocortisone to Zycortal, the authors have suggested the following protocol Day 1: Inject Zycortal at 2.2 mg/kg by subcutaneous injection once every 25 to 31 days and give the dog’s usual dose of fludrocortisone Day 2: Give the dog one half of the usual dose of fludrocortisone.

Is Zycortal a steroid?

How does Zycortal work? Desoxycortone pivalate is a synthetically produced steroid hormone very similar to the natural hormone aldosterone. It works in the same way as aldosterone to retain sufficient water in the body (by retaining sodium and eliminating potassium).

Does Zycortal cause hair loss in dogs?

In field studies and post‐approval experience, the most common side effects reported were: polyuria, polydipsia, depression/lethargy, pain on injection, weight gain, inappropriate urination, alopecia, decreased appetite/anorexia, panting, vomiting, diarrhea, shaking/trembling, polyphagia, urinary tract infection.

How is Zycortal administered?

The initial dose is 2.2 mg/kg (1 mg/lb) body weight, administered by subcutaneous injection.

Can Zycortal be given IM?

The studies all report an initial dose of 2.2 mg/kg of DOCP administered intramuscularly (IM), as opposed to the subcutaneous (SC) route for Zycortal.

How long does Zycortal last?

After subcutaneous administration of 11 mg/kg body weight (five times the labeled starting/initial dose of 2.2 mg/kg) of ZYCORTAL Suspension, the plasma half-life (mean ± standard deviation) is approximately 17 ± 7 days, with a maximum concentration (Cmax) of 13.2 ± 5 ng/mL, and time to maximum concentration (Tmax) of …

Can humans take Zycortal?

HUMAN WARNINGS: Not for human use. Keep this and all drugs out of the reach of children. Consult a physician in case of accidental human exposure.

Does Zycortal lower potassium?

Zycortal was found to be noninferior to Percorten-V in both management of clinical signs and control of serum sodium and potassium concentrations as evaluated at 90 days and 180 days after initiation of treatment.

Will my dog’s hair grow back after thyroid treatment?

You will typically see improvement in your dog’s activity level within a few weeks of starting thyroid hormone replacement therapy. However, hair regrowth takes longer, typically at least 4 months. Skin and ear problems also may take longer to clear up and require additional medications.

Is Zycortal FDA approved?

The alternative treatment option, Zycortal Suspension (desoxycorticosterone pivalate injectable suspension), is made by Dechra Veterinary Products. Both drugs are approved for use as replacement therapies for mineralocorticoid deficit in dogs with primary adrenocortical insufficiency, also known as Addison’s Disease.

Can Zycortal be given intramuscularly?

They differ in their use of preservative and surfactant. Percorten-V is labeled for intramuscular injection but is often given subcutaneously in clinical practice. Zycortal is labeled for subcutaneous injection.

What can Zycortal be used for in dogs?

Zycortal is indicated for use as replacement therapy for the mineralocorticoid deficit in dogs with primary hyperadrenocorticism (Addison’s disease). Type of inquiry * Please choose….

Are there any Dechra veterinary products in New Zealand?

Dechra Veterinary Products NZ – Veterinary pharmaceutical products for dogs, cats, horses, and farm animals. We’re all ears. Active where it’s needed 1.

How is Zycortal suspension used to treat Addison’s disease?

ZYCORTAL Suspension is given subcutaneously as replacement therapy for mineralocorticoid deficiency in dogs with primary hypoadrenocorticism (Addison’s disease) CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. As with all drugs, side effects may occur.

How long does it take for Zycortal to work?

The mean final dose for ZYCORTAL Suspension was 1.9 ± 0.27 mg/kg (range 1.2-2.5 mg/kg) and the mean final dose interval was 38.5 ± 12.5 days (range 20-99 days) with the majority of dogs having a dosing interval between 20 and 46 days.