What is the drug tositumomab used for?

The BEXXAR® therapeutic regimen (tositumomab and iodine I 131 tositumomab) is indicated for the treatment of patients with CD20-positive relapsed or refractory, low grade, follicular, or transformed non-Hodgkin’s lymphoma who have progressed during or after rituximab therapy, including patients with rituximab- …

What is tositumomab 131?

Iodine-131 tositumomab [B1, Bexxar , iodine-131 anti-B1 antibody] is a murine antibody conjugated to iodine 131 that recognises and binds to the B1 (CD20) antigen which is found specifically on B lymphocytes. Iodine-131 tositumomab has a dual mechanism of action.

Why was Bexxar discontinued?

In February 2014, GlaxoSmithKline discontinued the manufacture of the product, primarily because of a decline in use of 30% a year from 2006, its peak sales year.

Is Zevalin still available?

The In-111 Zevalin brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.

Is NHL curable?

Yes, NHL is a very treatable disease and curable in many cases, particularly with aggressive NHL. Before treatment begins, it is necessary to know how far the cancer has advanced. This is called the stage of the disease. The stages begin with I (least severe) and go through IV (most severe).

Is Avastin FDA approved?

FDA approves bevacizumab in combination with chemotherapy for ovarian cancer. On June 13, 2018, the Food and Drug Administration approved bevacizumab (Avastin, Genentech, Inc.)

How much does Zevalin cost?

The cost for Y-90 Zevalin intravenous kit (3.2 mg/2 mL) is around $59,342 for a supply of 1 kits, depending on the pharmacy you visit.

Who manufactures Zevalin?

Spectrum Pharmaceuticals Acquires 100% of ZEVALIN, an FDA-Approved, Proprietary, Biological Drug for Non-Hodgkin’s Lymphoma. IRVINE, Calif.