What is the difference between allogeneic and autologous?

Autologous: Auto means self. The stem cells in autologous transplants come from the same person who will get the transplant, so the patient is their own donor. Allogeneic: Allo means other. The stem cells in allogeneic transplants are from a person other than the patient, either a matched related or unrelated donor.

How is an allogeneic transplant performed?

A donor stem cell transplant replaces bone marrow that is not working properly with stem cells from another person (a donor).

What is an allogeneic bone marrow transplant?

In an allogeneic bone marrow transplant, the healthy stem cells come from the bone marrow of a related donor who is not an identical twin of the patient or from an unrelated donor who is genetically similar to the patient.

What is allogeneic cells?

In an allogeneic transplant, stem cells are collected from a matching donor and transplanted into the patient to suppress the disease and restore the patient’s immune system. An allogeneic stem cell transplant is different from an autologous stem cell transplant, which uses stem cells from the patient’s own body.

Is Gene Therapy autologous or allogeneic?

In principle, autologous gene therapy using hematopoietic stem cells (HSCs) as target cells provides an attractive alternative to allogeneic stem cell transplantation, since the gene therapy procedure will not trigger adverse events like graft-vs. -host disease or other immune complications (1–3).

What is the success rate of allogeneic transplant?

Among allogeneic recipients, 9 (23%) are currently alive, and actuarial disease-free survival at 7 years is 11%.

What chemo is used before allogeneic stem cell transplant?

“Mobilizing” stem cells means stimulating them to move from the marrow into the bloodstream, so that enough cells can be collected for an autologous transplant. The patient is then treated with high doses of chemotherapy, often using melphalan.

What is allogeneic product?

Allogeneic therapies are manufactured in large batches from unrelated donor tissues (such as bone marrow) whereas autologous therapies are manufactured as a single lot from the patient being treated. For some autologous therapies, the cells from the patient are processed on site at the clinic or hospital.

What is allogeneic antigen?

An antigen that occurs in some individuals of the same species. Examples are the human blood group antigens.

What does allogenic mean?

(A-loh-JEH-nik) Taken from different individuals of the same species.

How does allogeneic, or allo, transplant work?

In an allogeneic transplant, stem cells are donated to the patient from another person who is a genetically matched stem cell donor. This is usually a sibling with the same tissue type as the patient. Where no sibling is available, a search is made of Australian and overseas donor registries to find a suitably matched unrelated stem cell donor.

What does allogenic stem cell transplantation mean?

Allogeneic stem cell transplant. An allogeneic stem cell transplant uses healthy blood stem cells from a donor to replace your diseased or damaged bone marrow. An allogeneic stem cell transplant is also called an allogeneic bone marrow transplant. A donor may be a family member, an acquaintance or someone you don’t know.

What is the success rate of stem cell transplant?

Stem Cell Transplant Success Rates. Dubbed “one of the greatest success stories in cancer treatment”, bone marrow transplants aren’t exactly as successful as that label might imply. The notable Sloan Kettering Memorial Center brags about a 75% success rate versus a predicted 62% success rate.

Who can donate bone marrow or stem cells?

In the cases of both bone marrow and blood stem cell donation, the donor cells can be retrieved at a local hospital or blood donor room and shipped to where they are needed. The donor and recipient may live in different states, or even in different countries.