What is talazoparib used for?

Talazoparib is used to treat HER2-negative breast cancer that has spread to other parts of the body. Talazoparib is used only if your cancer has a specific genetic marker (an abnormal “BRCA” gene). Your doctor will test you for this gene. Talazoparib may also be used for purposes not listed in this medication guide.

Is Talazoparib FDA approved?

On October 16, 2018, the FDA approved talazoparib (Talzenna; Pfizer), an oral PARP inhibitor, for the treatment of adults with deleterious or suspected deleterious germline BRCA mutation–positive, HER2-negative locally advanced or metastatic breast cancer.

How does Talazoparib work?

Talazoparib is believed to work by inhibiting (stopping) the PARP proteins from working in tumor cells so that the cancer cannot fix its damaged DNA.

Is Talazoparib cytotoxic?

Mechanism of action. Talazoparib acts as an inhibitor of poly ADP ribose polymerase (PARP) which aids in single strand DNA repair. Cells that have BRCA1/2 mutations are susceptible to the cytotoxic effects of PARP inhibitors because of an accumulation of DNA damage.

How effective is talazoparib?

As secondary end points, the ORR was 62.6% (95% CI, 55.8–69.0) in the talazoparib group versus 27.2% (95% CI, 19.3–36.3) among those who received standard therapy. Twelve patients who received talazoparib (5.5%) had a complete response.

How do you pronounce talazoparib?

Pronunciation: (TA-luh-ZOH-puh-rib TOH-suh-layt) A drug used to treat HER2-negative breast cancer that is locally advanced or has spread to other parts of the body.

Does Talazoparib cause hair loss?

Hair loss was another side effect of talazoparib. While the percentage of women who experienced hair loss was about the same in the two treatment groups, women treated with talazoparib had milder hair loss than women treated with chemotherapy.

Who owns Talzenna?

Company: Pfizer Inc.

What are the side effects of talazoparib?

The most common side effects of Talzenna are:

• fatigue.
• anemia (low red blood cell counts)
• nausea.
• neutropenia (low white blood cell counts)
• headache.
• thrombocytopenia (low platelet counts)
• vomiting.
• hair loss.

What are the side effects of Talazoparib?

How do you pronounce Talazoparib?

How effective is Talazoparib?

What kind of cancer is Talazoparib used for?

Talazoparib is a poly-ADP ribose polymerase inhibitor used to treat HER2-, BRCA mutated locally advanced or metastatic breast cancer. Talazoparib was approved by the FDA for use in germline BRCA mutated, HER2 negative, locally advanced or metastatic breast cancer on October 16, 2018 under the trade name Talzenna 3.

Are there any side effects to taking talazoparib?

Talazoparib may also be used for purposes not listed in this medication guide. Using talazoparib may increase your risk of developing bone marrow problems or leukemia. Talazoparib can lower your blood cell counts, and you may get an infection or bleed more easily.

How is talazoparib related to acute liver injury?

Talazoparib is associated with a moderate rate of serum aminotransferase elevations during therapy and is suspected to cause rare instances of clinically apparent acute liver injury. Talazoparib prevents PARP-mediated repair of DNA damage in cancer cells, allowing accumulation of damage and PARP-DNA complexes [FDA Label].

When does Talazoparib reach its peak plasma concentration?

Talzenna capsules have a reach peak plasma concentration in 1-2 h Label. If taken with a high fat meal, Cmax decreases by 43%, Tmax increases by 1-4 h, and no change occurs in AUC. Talazoparib has a mean apparent volume of distribution of 420 L Label.