What is Granulocytopenia?

Listen to pronunciation. (GRAN-yoo-loh-SY-toh-PEE-nee-uh) A condition in which there is a lower-than-normal number of granulocytes (a type of white blood cell).

What medication causes Granulocytopenia?

Drugs that can cause agranulocytosis include:

• antithyroid medications, such as carbimazole and methimazole (Tapazole)
• anti-inflammatory medications, such as sulfasalazine (Azulfidine), dipyrone (Metamizole), and nonsteroidal anti-inflammatory drugs (NSAIDs)
• antipsychotics, such as clozapine (Clozaril)

What are symptoms of agranulocytosis?

Having very low levels of granulocytes in the blood can lead to serious or life-threatening infections. Signs and symptoms of agranulocytosis include fever, chills, weakness, sore throat, sores in the mouth or throat, bleeding gums, bone pain, low blood pressure, fast heartbeat, and trouble breathing.

Is leukopenia a form of cancer?

Different types of cancer, including leukemia, can lead to leukopenia. Cancer treatments can also cause leukopenia, including: chemotherapy. radiation therapy (especially when used on large bones, such as those in your legs and pelvis)

What is the cause of granulocytopenia?

Granulocytopenia may result from congenital or acquired defective production of granulocyte precursors or it may be a consequence of increased destruction of mature granulocytes, most frequently caused by immune mechanisms.

Which of the following cause is granulocytopenia?

It happens when the body doesn’t make enough of a type of white blood cells called neutrophils. White blood cells are part of the immune system. They protect the body from infection by fighting off germs that make us sick. Also known as granulocytopenia, agranulocytosis is a severe form of neutropenia.

Is granulocytopenia the same as neutropenia?

Also known as granulocytopenia, agranulocytosis is a severe form of neutropenia. Neutropenia is lower-than-normal levels of white blood cells.

Which antipsychotic can cause granulocytopenia?

Clozapine is a well-known drug that is used in treatment-resistant schizophrenia, but granulocytopenia, which may lead to a potentially fatal condition such as agranulocytosis, limit its use.

How long does it take for agranulocytosis?

Agranulocytosis usually develops in the first 3 months after ATD therapy is initiated [10], but cases after 5 days up to more than 10 years of exposure have also been described [22].

Which antipsychotic causes granulocytopenia?

What does high immature granulocytes mean?

A high immature granulocyte count means having more than 2% IGs in your white blood cell count. If your blood test shows up that you have increased white blood cell count and you also have a high immature granulocytes count, then your doctor will run further tests. Sometimes,…

What do low granulocytes mean?

Low levels of granulocytes reduce the body’s ability to fight infections [ 28 ]. Levels above this range are referred to as granulocytosis or neutrophilia. Under normal conditions, the immature granulocyte percentage (IG%) in our blood is less than 1%. Immature granulocyte levels increase rapidly during infections,… Nov 22 2019

What is granulocytes characteristics of?

Granulocytes are a category of white blood cells characterized by the presence of granules in their cytoplasm . They are also called polymorphonuclear leukocytes or polymorphonuclear neutrophils (PMN, PML, or PMNL) because of the varying shapes of the nucleus, which is usually lobed into three segments.

What are immature granulocytes and IG count?

Immature Granulocytes (IGs): What They Are and What IG Count Means. Immature granulocytes are immature white blood cells. The presence of immature granulocytes in blood test results usually means that your body is fighting an infection or inflammation.