What can myeloid stem cells differentiate into?

Myeloid stem cells give rise to a second level of lineage-specific CFU cells that go on to produce neutrophils, monocytes, eosinophils, basophils, mast cells, megakaryocytes, and erythrocytes. Monocytes differentiate further into macrophages in peripheral tissue compartments.

What is myeloid progenitor?

Myeloid progenitor cells are the precursors of red blood cells, platelets, granulocytes (polymorphonuclear leukocytes [PMNs]: neutrophils, eosinophils, and basophils), monocyte-macrophages, dendritic cells (DCs), and mast cells and osteoclasts.

What is myeloid differentiation?

Definition: The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.

How myeloid stem cells are differentiated into neutrophils?

Myeloid differentiation of stem cell progenitors Second, the promyelocytes are induced to become fully mature neutrophils by granulocyte-colony stimulating factor (G-CSF), which is added to the medium containing both SCF and IL-3.

What is progenitor cell?

Progenitor cells are descendants of stem cells that then further differentiate to create specialized cell types. There are many types of progenitor cells throughout the human body. Each progenitor cell is only capable of differentiating into cells that belong to the same tissue or organ.

Where are progenitor cells located?

They are in the “center” between stem cells and fully differentiated cells. The kind of potency they have depends on the type of their “parent” stem cell and also on their niche. Some progenitor cells were found during research, and were isolated.

What cells come from the myeloid progenitor?

In hematopoiesis, myeloid or myelogenous cells are blood cells that arise from a progenitor cell for granulocytes, monocytes, erythrocytes, or platelets (the common myeloid progenitor, that is, CMP or CFU-GEMM), or in a narrower sense also often used, specifically from the lineage of the myeloblast (the myelocytes.

What are myeloid lineages?

Cells of the myeloid lineage develop during the process of myelopoiesis and include Granulocytes, Monocytes, Megakaryocytes, and Dendritic Cells. Circulating Erythrocytes and Platelets also develop from myeloid progenitor cells.

Are myeloid progenitor cells stem cells?

Stem cells derived from HEMATOPOIETIC STEM CELLS. Derived from these myeloid progenitor cells are the MEGAKARYOCYTES; ERYTHROID CELLS; MYELOID CELLS; and some DENDRITIC CELLS.

Do progenitor cells differentiate?

Each progenitor cell is only capable of differentiating into cells that belong to the same tissue or organ. Some progenitor cells have one final target cell that they differentiate to, while others have the potential to terminate in more than one cell type.

What are progenitor cells?

Progenitor cell are very similar to stem cells. They are biological cells and like stem cells, they too have the ability to differentiate into a specific type of cell. However, they are already more specific than stem cells and can only be pushed to differentiate into its “target” cell.

What is a myeloid lineage cell?

How to model the differentiation of myeloid progenitors?

A systems view on the interactions of core transcription factors is important for understanding differentiation mechanisms and dynamics. In this manuscript, we construct a Boolean network to model myeloid differentiation, specifically from common myeloid progenitors to megakaryocytes, erythrocytes, granulocytes and monocytes.

Which is part of the myeloid differentiation pathway?

By single-cell transcriptome profiling of pre-GMs, we identified distinct myeloid differentiation pathways: a pathway expressing the gene encoding the transcription factor GATA-1 generated mast cells, eosinophils, megakaryocytes and erythroid cells, and a pathway lacking expression of that gene generated monocytes, neutrophils and lymphocytes.

How are myeloid cells differentiated in hematopoiesis?

Downstream of MPP are committed progenitors that are oligopotent and have limited ability to self-renew. As general principles, when cells progress through hematopoiesis they become more differentiated and more frequent in number.

How big is a myeloid progenitor bone cell?

This very large bone cell is up to 50–100 μm in diameter and can contain up to 100 nuclei [93]. Osteoclasts are derived from myeloid progenitor cells that also have the potential to develop into monocytes, macrophages, and dendritic cells.