Is lymphoproliferative a cancer disease?

Lymphoproliferative disorders (LPD) are common neoplasms that are primary or subsequent cancers in cases of multiple primary cancer.

What does CD30-positive mean?

CD30-positive cells characterize lymphomatoid papulosis and anaplastic large cell lymphoma but can also be found in nonneoplastic skin disorders. Purportedly, CD30 is useful in the differential diagnosis between insect bites and lymphomatoid papulosis.

What is CD30 test?

CD30 is a member of the tumor necrosis factor receptor (TNF-R) superfamily. Expression of CD30 can also be seen in embryonal carcinomas, malignant melanomas, mesenchymal tumors, and activated T and B lymphocytes and plasma cells.

Is lymphoproliferative disorder fatal?

Lymphoproliferative disease (LPD) is a recognized complication of immune dysregulation syndromes and primary immunodeficiency (PID). The recurrent lymphoproliferative disease is a post-transfusional complication. [12] PTLD may sometimes progress to non-Hodgkin lymphoma that can often be fatal.

What is CD30 lymphoma?

CD30 is a cell surface receptor expressed in classical Hodgkin lymphoma (HL), anaplastic large cell lymphoma (ALCL), and many other lymphomas to a variable degree. It has been identified as an important therapeutic target in lymphoma.

What is the final diagnosis of CD30 positive lymphoproliferative disorder?

Final Diagnosis — CD30 Positive Lymphoproliferative Disorder. DISCUSSION: This case illustrates the diagnostic challenges posed by a group of disorders known as CD30 positive lymphoproliferative disorders of the skin. Comprising this group are lymphomatoid papulosis (LYP), primary cutaneous anaplastic lymphoma (C-ALCL), and borderline cases.

Is there an intersection between CD30 + LPDs and LCT-MF?

There is substantial intersection between the CD30 + LPDs and CD30 + LCT-MF, all of which can show nearly identical clinical and histopathologic findings (particularly when the majority of tumor cells express CD30). Further, patients can exhibit multiple cutaneous CD30 + diagnoses concurrently or at different times.

What kind of lymphoma is LYP Type C?

Comprising this group are lymphomatoid papulosis (LYP), primary cutaneous anaplastic lymphoma (C-ALCL), and borderline cases. The differential diagnosis in the case presented includes LYP-Type C, C-ALCL, and skin involvement by systemic anaplastic large cell lymphoma.

Can a LYP Type B cell be CD30 negative?

The large atypical cells do not express CD8, CD7, or CD56. The cells may lose expression of CD3. In LYP type B the atypical cells are usually CD30 negative.