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Can sitagliptin be used in pregnancy?

Can sitagliptin be used in pregnancy?

Risk Summary: Limited data available with this drug in pregnant women are not sufficient to inform a drug-associated risk for major birth defects and miscarriage; there are risks to the mother and fetus associated with poorly controlled diabetes during pregnancy.

What are the indications of sitagliptin?

Sitagliptin is used with a proper diet and exercise program and possibly with other medications to control high blood sugar. It is used in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems.

Can I take Sitagliptin Metformin while pregnant?

There are no adequate and well controlled studies in pregnant women with metformin-sitagliptin. AU TGA pregnancy category C: Drugs which, owing to their pharmacological effects, have caused or may be suspected of causing, harmful effects on the human fetus or neonate without causing malformations.

Is JANUVIA good for pregnancy?

No dosage adjustment of digoxin or JANUVIA is recommended. Pregnancy Category B: Reproduction studies have been performed in rats and rabbits. Doses of sitagliptin up to 125 mg/kg (approximately 12 times the human exposure at the maximum recommended human dose) did not impair fertility or harm the fetus.

What is sitagliptin 100mg?

About sitagliptin Sitagliptin is a medicine used to treat type 2 diabetes. Type 2 diabetes is an illness where the body does not make enough insulin, or the insulin that it makes does not work properly. This can cause high blood sugar levels (hyperglycaemia).

Who should not use sitagliptin?

It shouldn’t be used in children younger than 18 years. As you age, your kidneys may not work as well as they once did. Your dosage of sitagliptin will depend on your kidney function. Your doctor will check your kidneys before and during treatment with this medication.

What pregnancy category is metformin?

Metformin has no known fetal teratogenicity and no known fetal harm, although it crosses the placenta readily, and it is unbound in serum (19). It remains Food and Drug Administration Category B during pregnancy.

What are the side effects of JANUVIA 100 mg?

The most common side effects of JANUVIA include upper respiratory infection, stuffy or runny nose and sore throat, and headache. JANUVIA may have other side effects, including stomach upset and diarrhea, swelling of the hands or legs, when JANUVIA is used with metformin and rosiglitazone (Avandia ®).

Can I just stop taking JANUVIA?

Don’t stop taking Januvia unless recommended by your doctor. If you stop taking it, your blood sugar levels will go back up.

What is the dosage of sitagliptin 100 mg?

Sitagliptin. Generic Name: sitagliptin (SI ta glip tin) Brand Name: Januvia. Dosage Forms: oral tablet (100 mg; 25 mg; 50 mg) Medically reviewed by on Dec 11, 2020. Written by Cerner Multum. Uses. Warnings. What to avoid.

How to report side effects of sitagliptin to the FDA?

You may report side effects to FDA at 1-800-FDA-1088. -When used in combination with an insulin secretagogue (e.g. sulfonylurea) or insulin, a lower dose of the insulin secretagogue or insulin may be required to reduce the risk of hypoglycemia.

Is it safe to take sitagliptin while pregnant?

Limited available data in pregnant females are not sufficient to inform a drug-associated risk for major birth defects and miscarriage There is no information regarding presence of drug in human milk, effects on breastfed infants, or on milk production A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

How is sitagliptin used to treat type 2 diabetes?

Sitagliptin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Sitagliptin is not for treating type 1 diabetes. Sitagliptin may also be used for purposes not listed in this medication guide.