What are the genomic landscapes of human cancer?

Abstract. Over the past decade, comprehensive sequencing efforts have revealed the genomic landscapes of common forms of human cancer. For most cancer types, this landscape consists of a small number of “mountains” (genes altered in a high percentage of tumors) and a much larger number of “hills” (genes altered infrequently).

Are there any RNA editing events in cancer?

We characterized the global A-to-I RNA editing profiles of 6,236 patient samples of 17 cancer types from The Cancer Genome Atlas and revealed a striking diversity of altered RNA-editing patterns in tumors relative to normal tissues. We identified an appreciable number of clinically relevant editing events, many of which are in noncoding regions.

Where can I find the genome of cancer?

Science. 2013 Mar 29;339 (6127):1546-58. doi: 10.1126/science.1235122. 1 The Ludwig Center and The Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA. Over the past decade, comprehensive sequencing efforts have revealed the genomic landscapes of common forms of human cancer.

Who is involved in the Cancer Genome Atlas?

The Cancer Genome Atlas (TCGA) is a joint effort of the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI), which are both part of the National Institutes of Health, U.S. Department of Health and Human Services. The Cancer Genome Atlas will assess the feasibility of a full-scale effort…

When was the cancer genome published in nature?

Published in final edited form as: Nature. 2009 Apr 9; 458(7239): 719–724. doi: 10.1038/nature07943 PMCID: PMC2821689 EMSID: UKMS27394 PMID: 19360079 The cancer genome Michael R. Stratton,1,2Peter J. Campbell,1,3and P. Andrew Futreal1 Michael R. Stratton 1Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK