What is the most common drug induced thrombocytopenia in hospitalized patients?

What is the most common drug induced thrombocytopenia in hospitalized patients?

Heparin, a blood thinner, is the most common cause of drug-induced immune thrombocytopenia. If a medicine prevents your bone marrow from making enough platelets, the condition is called drug-induced nonimmune thrombocytopenia. Chemotherapy drugs and a seizure medicine called valproic acid may lead to this problem.

At what level does thrombocytopenia become critical?

Dangerous internal bleeding can occur when your platelet count falls below 10,000 platelets per microliter. Though rare, severe thrombocytopenia can cause bleeding into the brain, which can be fatal.

When should you be hospitalized for thrombocytopenia?

Hospitalization has been suggested for children with ITP who have severe life-threatening bleeding or platelet counts of less than 20×109/L and mucous membrane bleeding; but the value of hospitalization for patients presenting with platelet counts of less than 20×109/L, petechiae and purpura, who are otherwise …

Which drugs cause low platelets?

Heparin, a blood thinner, is the most common cause of drug-induced immune thrombocytopenia….Other medicines that cause drug-induced thrombocytopenia include:

  • Furosemide.
  • Gold, used to treat arthritis.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Penicillin.
  • Quinidine.
  • Quinine.
  • Ranitidine.
  • Sulfonamides.

Which medications can cause thrombocytopenia?

Some prescribed medications can also cause thrombocytopenia, including:

  • amiodarone.
  • ampicillin and other antibiotics.
  • cimetidine.
  • piperacillin.
  • seizure medications, such as carbamazepine.
  • sulfonamides, such as trimethoprim-sulfamethoxazole.
  • vancomycin.

How do hospitals increase platelet count?

If your platelet level becomes too low, your doctor can replace lost blood with transfusions of packed red blood cells or platelets. Medications. If your condition is related to an immune system problem, your doctor might prescribe drugs to boost your platelet count. The first-choice drug might be a corticosteroid.

How is platelet transfusion done?

A platelet transfusion is when you are given platelets from carefully screened donors. Sometimes this is called a platelet infusion. You will be given platelets by a drip into one of your veins. This increases the number of platelets in your blood.

When do you admit with low platelets?

In their discussion, the authors suggest that children with a very low platelet count (less than 5·109/L) or significant mucosal bleeding, or families where geographic location and community resources may hinder obtaining urgent care should be admitted.

Can you be hospitalized for low platelets?

Treatment is based on the etiology and, in some cases, treating the secondary cause results in normalization of platelet counts. Consultation with a hematologist should be considered if patients require hospitalization, if there is evidence of systemic disease, or if thrombocytopenia worsens despite initial treatment.

How often does thrombocytopenia occur in ICU patients?

• A 2011 systematic review of 6,894 critically ill patients – -8% to 68% of patients had thrombocytopenia on admission to the intensive care unit (ICU) -13% to 44% of patients developed it during their ICU stay. -Thrombocytopenia correlated with high-severity illness, sepsis, and organ dysfunction.

What are the odds of dying from thrombocytopenia?

• In almost all patient populations, thrombocytopenia – an ominous sign. – In critically ill patients, thrombocytopenia was an independent predictor of death in hospital (odds ratio [OR], 2. 1–26. 2) and in the ICU (OR, 3. 1–4. 2) across six observational studies (N 6,894).

How often does thrombocytopenia occur after heart surgery?

In a study of 581 patients who underwent cardiac surgery with cardiopulmonary bypass, thrombocytopenia occurred in 56.3% of patients within 10 days of surgery. Similar decreases in the platelet counts with other surgeries.

What should a doctor ask a patient about thrombocytopenia?

A systematic approach should be used to evaluate incidental thrombocytopenia. During the patient history, physicians should inquire about easy bruising or petechiae, melena, rashes, fevers, and bleeding. They also should inquire about medication use, immunizations, recent travel, transfusion history, family history, and medical history.