What is retinol binding protein test?

Retinol-binding protein (RBP) is the most sensitive measure of protein status. It is a low-molecular-weight protein that responds to both protein and calorie restrictions. RBP is not a reliable indicator of protein status in advanced chronic renal disease.

What does high retinol binding protein mean?

High Circulating Retinol-Binding Protein 4 Is Associated With Elevated Liver Fat but Not With Total, Subcutaneous, Visceral, or Intramyocellular Fat in Humans.

What type of protein is retinol binding protein?

Retinol Binding Protein (RBP), a single-chain polypeptide glycoprotein, belongs to the a-globulin family of human plasma proteins and is the primary plasma transport protein for retinol (vitamin A1). RBP binds retinol in a 1:1 stoichiometry, serving not only to solubilize retinol but also to protect it from oxidation.

Is retinol binding protein a positive or a negative acute phase protein?

During the acute phase response the synthesis of negative acute phase proteins, such as retinol binding protein (RBP), decreases (13). This contributes to the lower serum concentration of these proteins, although other factors also contribute (4, 14).

Is transthyretin the same as retinol-binding protein?

Retinol transport complex consisting of retinol-binding protein (RBP) and transthyretin (TTR) is involved in the transport of retinol (vitamin A) and thyroxine (T(4)) in the human plasma. RBP is a 21-kDa single polypeptide chain protein, synthesized in the liver, which binds and transports retinol to the target organs.

Whats the meaning of RBP?

Abbreviation for retinol-binding protein.

Where is retinol-binding protein found?

Retinol-binding protein is most often found bound to transthyretin, but a small, unbound fraction (<10%) passes freely through glomerular membranes and is reabsorbed by renal proximal tubules cells where it is catabolised.

What is a positive acute phase protein?

Positive acute-phase proteins increase in plasma concentration in response to inflammation (usually within 1-2 days). Positive APPs are further categorized as major, moderate or minor, depending on the degree of increase.

What is TTR gene?

The TTR gene provides instructions for producing a protein called transthyretin. This protein transports vitamin A (retinol) and a hormone called thyroxine throughout the body. To transport thyroxine, four transthyretin proteins must be attached (bound) to each other to form a four-protein unit (tetramer).

What is serum transthyretin?

Serum Transthyretin (Prealbumin) Transthyretin is a minor thyroid-binding globulin and a co-carrier of vitamin A with retinol-binding protein. 81. Its half-life of approximately 2 days makes its serum concentrations responsive to recent changes in protein-energy intake.

What is the meaning of RBP in FB?

This is only my understanding of what is RBP is,It stands for Reply Box Policy, wherein there is a strict rules to follow when commenting towards the work or the story.it is a kind of instruction that a reader is obliged to do to avoid unnecessary confusion for the benifet of all.

What is the molecular weight of retinol binding protein 4?

NP_035385. Retinol binding protein 4, also known as RBP4, is a transporter protein for retinol (vitamin A alcohol). RBP4 has a molecular weight of approximately 21 kDa and is encoded by the RBP4 gene in humans.

Where does RBP4 deliver retinol to the body?

RBP4 may also be involved in metabolic diseases as suggested by recent studies. This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A) in the blood. It delivers retinol from the liver stores to the peripheral tissues.

What does serum concentration of retinol binding protein indicate?

Serum concentrations reflect the synthesis capacity of the liver and may indicate early malnutrition, acute and chronic hepatic disease, advanced chronic renal insufficiency, and cystic fibrosis. Assess nephritic syndrome and protein-losing enteropathy.

How does RBP-retinol complex interact with transthyretin?

In plasma, the RBP-retinol complex interacts with transthyretin, which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells.