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What is Carcinomatous meningitis?

What is Carcinomatous meningitis?

Carcinomatous meningitis is the dissemination of malignant cells from the primary tumor sites to leptomeningeal layers of the CNS. It occurs in the advanced stage of any cancer, solid as well as hematological malignancies. It is a rare complication with a dismal prognosis.

Is Carcinomatous a terminal of meningitis?

Carcinomatous meningitis, specifically leptomeningeal metastases from solid tumors, has a dismal prognosis, with an overall median survival of 2 to 4 months.

How is Leptomeningeal Carcinomatosis diagnosed?

The diagnosis is most commonly made by lumbar puncture although the CSF cytology is persistently negative in about 10% of patients with leptomeningeal carcinomatosis. Radiologic studies may reveal subarachnoid masses, diffuse contrast enhancement of the meninges, or hydrocephalus without a mass lesion.

What is Leptomeningeal meningitis?

Leptomeningeal metastases mean cancer cells have spread to the thin layers of tissue that cover the brain and spinal cord (the leptomeninges). It is also called: carcinomatosis meningitis.

What does Sarcomatous mean?

Sarcoma is a type of cancer that can occur in various locations in your body. Sarcoma is the general term for a broad group of cancers that begin in the bones and in the soft (also called connective) tissues (soft tissue sarcoma).

What is the prognosis for Leptomeningeal?

Despite advances in targeted radiation and chemotherapy, survival remains poor after diagnosis of leptomeningeal involvement, averaging 3–6 months. Survival varies by etiology, with breast cancer patients having the best prognosis (13–25% survival at one year and 6% at two years) [1, 4, 5].

What is Fibromyxoid sarcoma?

FY-broh-MIK-soyd sar-KOH-muh) A rare, slow-growing type of cancer that usually forms in the deep soft tissues of the legs or trunk (chest and abdomen). The cancer may come back many years after treatment and spread to the lungs and the lining of the wall of the chest cavity.

Which is CSF protein levels suggest viral meningitis?

The CSF protein level (reference range, 20-50 mg/dL) is usually elevated in bacterial meningitis. In viral meningitis, these levels are also usually elevated, though they can be within the reference range.

Which are the tests to confirm bacterial meningitis?

You or your child may undergo the following diagnostic tests: Blood cultures. Blood samples are placed in a special dish to see if it grows microorganisms, particularly bacteria. Imaging. Computerized tomography (CT) or magnetic resonance imaging (MRI) scans of the head may show swelling or inflammation. Spinal tap (lumbar puncture).

What is the diagnostic test for meningitis?

Cerebrospinal fluid test. This is the only test that can truly diagnose meningitis. To perform this test, your doctor inserts a needle into your spine in order to collect cerebrospinal fluid (CSF) that’s found around your brain and spinal cord. Then, your doctor sends your CSF to a lab for testing.

What is Spinal menigitis?

spinal meningitis. n. Inflammation of the membranes enclosing the spinal cord, especially a usually fatal form that affects infants and young children and is caused by a strain of gram-negative bacteria ( Hemophilus influenzae ) formerly thought to cause influenza.