What does granulocyte colony-stimulating factor do?

Granulocyte colony-stimulating factor helps the bone marrow make more white blood cells. It is a type of colony-stimulating factor. Also called filgrastim and G-CSF.

Where is granulocyte colony-stimulating factor?

G-CSF is produced by endothelium, macrophages, and a number of other immune cells.

What is the difference between G-CSF and GM-CSF?

The G-CSF receptor (G-CSFR; CD114) is a homo-oligo-dimer, whereas the GM-CSF receptor (GM-CSFR; CD116) is a hetero-oligo-dimer sharing a β-chain with the IL-3 and IL-5 receptors. The G-CSFR is expressed primarily on neutrophils and bone marrow precursor cells.

What are the side effects of Nivestim?

The most common side effects with Nivestim (which may affect more than 1 in 10 people) are fever, musculoskeletal pain (pain in the muscles and bones), anaemia (low red blood cell counts), vomiting and nausea (feeling sick).

Can Neupogen cause leukemia?

This medicine may cause blood or bone marrow problems (eg, myelodysplastic syndrome, acute myeloid leukemia) in patients with breast or lung cancer.

When do you give granulocyte colony-stimulating factor?

Therapy usually begins 1 to 3 days after chemotherapy ends. Granulocyte colony-stimulating factor is injected into the fatty portion of the skin, usually in the upper arm, thigh, or abdomen. To avoid infection, you should wash your hands before and after the injection and clean the injection site.

Why is filgrastim given 24 hours after chemotherapy?

This medication is usually given at least 24 hours after chemotherapy to stimulate the growth of new, healthy, white blood cells (WBC). Pegfilgrastim is a longer acting form of filgrastim and the manufacturer recommends that it should not be given within 14 days prior to chemotherapy.

What cells produce G-CSF?

Human G-CSF is produced mainly by monocytes and macrophages (2), but is also produced by fibroblasts (3), endothelial cells (4), and bone marrow stromal cells (5).

What is the difference between filgrastim and pegfilgrastim?

Treatment regimens differ slightly: filgrastim is administered daily for up to a maximum of 14 days, either subcutaneously or intravenously, whereas pegfilgrastim treatment involves a single SC dose per chemotherapy cycle with no restrictions to every 14-day cycles only.

When should I stop GCSF?

GCSF doses and duration of therapy Refer to the relevant Network chemotherapy protocol for the regimen. Stop the GCSF once neutrophils ≥ 1.0 x 109/l for 2 consecutive days. The optimum duration may be 7 days however some Clinicians may wish to stop after 5 days.

How long does it take nivestim to work?

are only required to use Nivestim for short periods of time until the number of infection-fighting neutrophils are restored (usually 1 to 3 weeks). should receive Nivestim treatment for 4 to 5 days.

When to use granulocyte colony stimulating factor ( G-CSF )?

Granulocyte colony stimulating factor (G-CSF) G-CSF is a type of growth factor. You might have G-CSF after chemotherapy to help your white blood cells recover after treatment. Or you might have it before and after a stem cell transplant.

Which is a glycoprotein that stimulates the release of granulocytes?

Granulocyte colony-stimulating factor ( G-CSF or GCSF ), also known as colony-stimulating factor 3 ( CSF 3 ), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream.

How does G-CSF affect hematopoietic stem cell mobilization?

G-CSF is also a potent inducer of hematopoietic stem cell (HSC) mobilization from the bone marrow into the bloodstream, although it has been shown that it does not directly affect the hematopoietic progenitors that are mobilized.

How does G-CSF work in the central nervous system?

G-CSF can also act on neuronal cells as a neurotrophic factor. Indeed, its receptor is expressed by neurons in the brain and spinal cord. The action of G-CSF in the central nervous system is to induce neurogenesis, to increase the neuroplasticity and to counteract apoptosis.