What can cause elevated chromogranin A?

CgA levels may be elevated in conditions such as liver disease, inflammatory bowel disease, pancreatitis, chronic bronchitis, renal insufficiency, and stress. These possible causes for elevated CgA levels should be considered when interpreting test results.

Is chromogranin a fasting blood test?

Measurements may vary with meal consumption, so patients are required to fast before a CgA test. CgA tests are performed every 3 to 6 months. *CgA is a protein found in carcinoid tumor cells, and it may be secreted into the blood. A blood sample is taken, and the level of CgA in the bloodstream is determined.

What does high chromogranin mean?

(KROH-moh-GRA-nin …) A protein found inside neuroendocrine cells, which release chromogranin A and certain hormones into the blood. Chromogranin A may be found in higher than normal amounts in patients with certain neuroendocrine tumors, small cell lung cancer, prostate cancer, and other conditions.

What does chromogranin positive mean?

Adrenal system tumors that stain positive for chromogranin A include pheochromocytoma. Lung tumors include small cell cancer. Elevation in serum CgA correlates with the size, extension and the histopathology of the neuroendocrine tumors; it is usually higher in large, metastatic, and well-differentiated tumors.

What is chromogranin function?

Function. Chromogranin A is the precursor to several functional peptides including vasostatin-1, vasostatin-2, pancreastatin, catestatin and parastatin. These peptides negatively modulate the neuroendocrine function of the releasing cell (autocrine) or nearby cells (paracrine).

What does a high chromogranin mean?

A protein found inside neuroendocrine cells, which release chromogranin A and certain hormones into the blood. Chromogranin A may be found in higher than normal amounts in patients with certain neuroendocrine tumors, small cell lung cancer, prostate cancer, and other conditions.

Which is the best chromogranin A test result?

CHROMOGRANIN A Optimal Result: 25 – 140 ng/mL. The Chromogranin A test may be used to help detect, diagnose, and/or monitor neuroendocrine tumors, especially carcinoid tumors. Chromogranin A is a protein released from neuroendocrine cells.

How are serum levels of CGA and NSE determined?

Serum levels of CgA, neuron-specific enolase (NSE), and the α-subunit of glycoprotein hormones (α-SU) were determined in 211 patients with neuroendocrine tumors and 180 control subjects with nonendocrine tumors. The concentrations of CgA, NSE, and α-SU were elevated in 50%, 43%, and 24% of patients with neuroendocrine tumors, respectively.

Can a person with normal chromogranin A have a tumor?

A person with no signs or symptoms and a normal level of Chromogranin A is unlikely to have a neuroendocrine tumor. However, the test is not perfect, and it is possible to have a neuroendocrine tumor even if the concentration of CgA is normal. What does it mean if your CHROMOGRANIN A result is too high?

Who are the control group for chromogranin A?

This control group consisted of patients with breast carcinoma (n = 64), nonsmall cell lung cancer (n = 24), pancreatic adenocarcinoma (n = 21), adenocarcinoma of unknown origin (n = 12), non-Hodgkin lymphoma (n = 25), Hodgkin lymphoma (n = 13), multiple myeloma (n = 7), meningioma (n = 10), and astrocytoma (n = 4).