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Is there still a role for cyclophosphamide in the treatment of systemic sclerosis?

Is there still a role for cyclophosphamide in the treatment of systemic sclerosis?

Treatment with cyclophosphamide has shown survival benefit in patients with SSc-ILD in a retrospective study; however, a survival benefit of 1-year treatment with oral cyclophosphamide was not found in the SLS I and SLS II.

Does scleroderma shorten your life?

Background: Scleroderma is a rare connective tissue disorder characterised by inflammation, vasculopathy and excessive fibrosis. Patients with scleroderma are known to have decreased life expectancy.

What celebrities have scleroderma?

It also features the stories of some well-known celebrities, including football icon Barry Sanders, TV stars Jason Alexander and Mark Teich, and author Mitch Albom. Connie Pulver shared her story in a new video produced by the Scleroderma Foundation.

Can scleroderma turn into lupus?

Systemic lupus erythematosus (SLE), is an autoimmune condition, which causes inflammation and damage to the joints, muscles, kidneys and other organs. Around 20% of people with scleroderma also have lupus as a cross-over condition or ‘overlap syndrome’.

Is lupus related to scleroderma?

Scleroderma is one of the most common “overlap diseases” for those living with lupus, with about 20% of those with scleroderma also having lupus. Learn about the complexities of scleroderma including its symptoms, possible complications and the most common ways to manage this autoimmune disease.

Why is scleroderma fatal?

Not only can it affect the skin, but it also can affect many internal organs, hindering digestive and respiratory functions, and causing kidney failure. Systemic scleroderma can sometimes become serious and life-threatening.

How much cyclophosphamide can you take in a day?

Oral cyclophosphamide dosing is usually in the range of 1 mg per kg per day to 5 mg per kg per day for both initial and maintenance dosing.

How does cyclophosphamide work for interstitial lung disease?

One year of oral cyclophosphamide in patients with symptomatic scleroderma-related interstitial lung disease had a significant but modest beneficial effect on lung function, dyspnea, thickening of the skin, and the health-related quality of life.

What should I do after IV cyclophosphamide treatment?

IV Administration. To minimize bladder toxicity, increase normal fluid intake during and for 1-2 days after cyclophosphamide therapy; most adult patients will require fluid intake of at least 2 L/day; high-dose regimens should be accompanied by vigorous hydration with or without mesna therapy.

Are there any side effects to taking cyclophosphamide?

Cyclophosphamide is contraindicated in patients who have a history of severe hypersensitivity reactions to it, any of its metabolites, or to other components of the product. Anaphylactic reactions including death have been reported with cyclophosphamide. Possible cross-sensitivity with other alkylating agents can occur.