How long does it take for D-dimer to normalize after DVT?

How long does it take for D-dimer to normalize after DVT?

15 to 20 days
After a thrombotic event, D-d levels may normalize within 15 to 20 days20,23 and are probably most useful for diagnosis within 11 days of symptom onset.

How long does D-dimer take to return to normal?

Median time to follow-up was 80.5 days after initial diagnosis. Results showed a median D-dimer level of 327 ng/mL, considered within the normal local range. However, 25.3% of patients had D-dimer levels higher than 500 ng/mL up to 4 months after diagnosis, with a median D-dimer level of 744 ng/mL among this group.

How often is D-dimer false positive?

However, low specificity limits the usefulness of D-dimer testing. Specificity is typically between 40% and 60%, leading to a high rate of false-positive results. Several factors, other than PE or deep vein thrombosis (DVT), are associated with positive D-dimer results.

Is DVT recurrent?

Deep-vein thrombosis (DVT) is regarded a chronic disease as it often recurs. DVT affects most frequently the lower limbs and hence DVT of the leg will be the focus of this article.

Does D-dimer rule out DVT?

A negative D-dimer result means that DVT or PE can be ruled out. A positive D-dimer result means that the patient has to undergo further imaging in order to diagnose whether or not he or she has DVT or PE. This makes ruling out the main purpose of the D-dimer test.

How accurate is D-dimer for DVT?

D-dimer sensitivity and specificity for isolated distal DVT were 84% (95% CI 75-91%) and 50% (95% CI 46-54%), respectively, with a negative predictive value of 96% (95% CI 93-98%). In patients with low pretest clinical probability, the D-dimer negative predictive value was 99% (95% CI 95-100%).

Can anxiety cause elevated D-dimer?

The independent association of anxiety symptoms with resting and stress-induced fibrin formation (D-dimer) may be a mechanism linking mood with cardiovascular disease risk in the elderly.

Why do I keep getting DVT?

Blood clot in leg vein You can get DVT if you have certain medical conditions that affect how your blood clots. A blood clot in your legs can also happen if you don’t move for a long time, such as after you have surgery or an accident, when you’re traveling a long distance, or when you’re on bed rest.

What can cause recurrent DVT?


  • pregnancy.
  • surgery, especially total knee or hip arthroplasty.
  • use of birth control.
  • inflammatory bowel disease, such as Crohn’s disease or ulcerative colitis.
  • prolonged sitting, such as on an airplane.
  • being bedridden.
  • genetic conditions, such as protein S deficiency or factor V Leiden mutation.
  • smoking.

How accurate are D-dimer tests for DVT?

[52] assessed D-dimer levels in 1068 patients with suspected DVT. The sensitivity of D-dimer was 86% and 83% in patients with and without cancer, respectively.

How often does thromboembolism recur in D-dimer patients?

A total of 18 events occurred among the 120 patients who stopped anticoagulation (15.0%), as compared with 3 events among the 103 patients who resumed anticoagulation (2.9%), for an adjusted hazard ratio of 4.26 (95% confidence interval [CI], 1.23 to 14.6; P=0.02). Thromboembolism recurred in 24 of 385 patients with a normal d -dimer level (6.2%).

How are D-dimer levels affected by anticoagulation?

Unfortunately, no information is available on their d-dimer levels (or those of the other patients) on the day anticoagulation was stopped. It is therefore impossible to comment on the relationship between d-dimer levels during anticoagulation and the risk of early recurrence after interruption of therapy.

Is there a benefit to prolonged D-dimer treatment?

Discussion. The risk–benefit relationship of prolonged anticoagulation in patients with a normal d -dimer level is therefore uncertain. In contrast, there was a clear benefit of prolonged treatment with vitamin K antagonists in patients whose d -dimer levels were abnormal a month after the discontinuation of anticoagulation.

When to resume D-dimer testing after discontinuation?

Patients with an abnormal d-dimer level 1 month after the discontinuation of anticoagulation have a significant incidence of recurrent venous thromboembolism, which is reduced by the resumption of anticoagulation.